TIP UPJŠ · Košice, Slovakia · B2B commercialization platform

Published bioactive compounds and protein platforms — ready to run as your pilot in 4 to 12 weeks.

Metabolite Market gives R&D teams in pharma, cosmetics, nutraceuticals and industrial biotechnology direct access to four research groups at Pavol Jozef Šafárik University in Košice: lichen-derived actives with peer-reviewed in vitro data, cell-free protein variant screening, enzyme engineering, biophysical stability mapping and custom synthesis. Indicative prices are published. An NDA is available before you disclose anything. You work with the scientists, not with an account manager.

Book a 30-minute discovery call Request a technical brief

Peer-reviewed source data, linked by DOI
NDA available before disclosure
Pilots in 4–12 weeks
Indicative prices published
B2B only — not an e-shop

Every inquiry is acknowledged within one working day and answered by the responsible group leader within three.

Portfolio at a glance

21Compounds & platformsAcross three portfolio lines
6Engagement modelsFrom a free call to co-development
4Peer-reviewed sourcesCited and linked under Evidence
1 dAcknowledgementAnswer from the group leader within three

Three portfolio lines

Find the compound, platform or service that fits your programme.

Portfolio A

Secondary Metabolites

Lichen-derived depsides, depsidones and dibenzofurans with published antioxidant, antiproliferative and antimicrobial data, plus multi-species extract panels.

7 entries · A1–A7 Portfolio B

Proteins & Enzymes

Variant screening, directed evolution, biophysical stability mapping and purification workflows from the Centre for Interdisciplinary Biosciences.

7 entries · B1–B7 Portfolio C

Organic Synthesis

Fluorescent probes for reactive species, sphingolipid analogues and saccharide building blocks — synthesised to order, in custom quantities.

7 entries · C1–C7

Search the full portfolio

Usually the right first project

Three entry points with the shortest route to a decision.

Protein biophysics · Formulation support

Protein Stability & Formulation Platform

Know before you formulate. DSC, fluorescence probes and dynamic light scattering map thermodynamic and kinetic stability; buffer, salt and pH screening and aggregation risk profiling are run on your protein rather than on a generic prediction.

Evidence: Method portfolio · report under NDA
Stage: Pilot-ready
Indicative: € 8 000 – 50 000negotiable by scope and application

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A7Fastest entry point

Standardised crude / semi-purified extracts · 5–10 species

Lichen Extract Bioactivity Panels

The quickest way to see what lichen chemistry can do for your pipeline. Panels of Pseudevernia furfuracea, Lobaria pulmonaria, Cetraria islandica, Umbilicaria hirsuta and related species, with HPLC/LC-MS profiling plus antioxidant, antimicrobial and cell viability assays. You receive a shortlist of active candidates with data.

Evidence: Peer-reviewed 2023 · profiling data
Stage: Pilot-ready · 8–12 weeks
Indicative: € 8 000 – 40 000lead isolation quoted individually

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A1Lead compound

Depside · Umbilicaria hirsuta

Gyrophoric Acid Platform

The best-characterised compound in the portfolio. Published work reports ROS production, apoptosis and modulation of Akt, Erk1/2 and p38 MAPK in HeLa cells, with a validated isolation protocol giving high-purity material.

Evidence: Peer-reviewed 2019 · mechanistic dataset
Stage: Pilot-ready · licensing open
Indicative: € 8 000 – 35 000negotiable by scope and application

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By industry

What this portfolio is used for.

Pharma & Biotech

Mechanistic in vitro data on isolated compounds, cell-free variant screening, biophysical stability mapping and custom synthesis — delivered as…

Cosmetics

Lichen-derived antioxidants compared per mole rather than per unit weight, multi-species extract panels, and the full phytosphingosine stereoisomer…

Nutraceuticals

Antioxidant, antimicrobial and cell-viability screening of standardised natural material, with HPLC/LC-MS profiling and a ranked candidate shortlist…

Industrial Biotechnology

Directed evolution and display selection applied to your substrate and your process conditions, protein purification workflow design, and condition…

Evidence

What is published, what is preliminary, and what sits under NDA.

Four research groups. Four peer-reviewed source publications, each linked by DOI so you can check them yourself. Every entry is labelled as published evidence, preliminary data, pilot-ready capability or research-use-only — and we do not blur the difference. All published findings referenced here are in vitro and are not clinical, therapeutic or regulatory claims.

See the four source publications

Questions industry visitors ask first

Is this an online shop?

No. Compounds and platforms are offered as research engagements — feasibility scans, pilots, custom synthesis, licensing and co-development. Every scope is agreed in writing before work starts.

Who will we actually work with?

The research group that does the work. Four group leaders are named on the team page, each with the publications behind their line.

How does an engagement start?

With a free 30-minute discovery call. We establish whether there is a fit and what the right next step is. Nothing is committed at that point.

Can we sign an NDA before we describe our project?

Yes. Tick the NDA box on the inquiry form and we arrange it before any disclosure.

Are the prices on this site binding?

No. They are indicative ranges so that you can size a project before contacting us. Final terms are negotiated per scope.

How quickly do you reply?

Every inquiry is acknowledged within one working day and answered by the responsible group leader within three.

What happens if you cannot help?

We say so, early, and where we can we point you to someone who can. A negative feasibility answer delivered quickly is a useful result.

Tell us what you are trying to achieve.

A free 30-minute call establishes whether there is a fit and what the right next step is. Every inquiry is acknowledged within one working day and answered by the responsible group leader within three.

Book a 30-minute discovery call Send an inquiry instead